Fast detection of deletion breakpoints using quantitative PCR
نویسندگان
چکیده
منابع مشابه
Fast detection of deletion breakpoints using quantitative PCR
The routine detection of large and medium copy number variants (CNVs) is well established. Hemizygotic deletions or duplications in the large Duchenne muscular dystrophy DMD gene responsible for Duchenne and Becker muscular dystrophies are routinely identified using multiple ligation probe amplification and array-based comparative genomic hybridization. These methods only map deleted or duplica...
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1p/19q (1p and/or 19q) deletions are prognostic factors in oligodendroglial tumors (OT) and predict better survival after both chemotherapy and radiotherapy. While studying 1p/19q status as a potential variable within multivariate prognosis models for OT, we have frequently encountered unknown 1p/19q status within our glioma sample database due to lack of paired blood samples for loss of hetero...
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Deletion and translocation mutations have been shown to play a significant role in the genesis of many cancers. The hprt gene located at Xq26 is a frequently used marker gene in human mutational studies. In an attempt to better understand potential mutational mechanisms involved in deletions and translocations, inverse PCR (IPCR) methods to amplify and sequence the breakpoints of hprt mutants c...
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Debuggers allow a user to halt a program and examine its state. The debugger stops execution when some user-speci ed condition is satis ed: Code breakpoints halt program execution when a particular instruction is executed. Data breakpoints halt program execution when a variable is referenced. Code breakpoints are supported directly in hardware on most machines and are fast. Data breakpoints, ho...
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ژورنال
عنوان ژورنال: Genetics and Molecular Biology
سال: 2016
ISSN: 1678-4685,1415-4757
DOI: 10.1590/1678-4685-gmb-2015-0159